Protein Domain : Eukaryotic/archaeal PrmC-related IPR004557

Type  Family
Description  These proteins exhibit homology to the Saccharomyces cerevisiae Mtq2 (also know as PrmC [ ]). Mtq2 methylates eRF1 on 'Gln-182' using S-adenosyl L-methionine as methyl donor. eRF1 needs to be complexed to eRF3 in its GTP-bound form to be efficiently methylated [, , ]. In bacteria, the methylation of RF1/RF2 by PrmC is important for normal growth, to increase the affinity of RF1/RF2 for ribosomes and to enhance translation termination [, ].Human homologue of Mtq2 is called hemK methyltransferase family member 2 (HEMK2, also known as N6AMT1), which is an N6-adenine-specific DNA methyltransferase [ ].
Short Name  PrmC-related

0 Child Features

1 Gene Families

99 Genes

1 Ontology Annotations

0 Parent Features

14 Publications

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