v5.1.0.3
Glycine data from LIS
Type | Family |
Description | These proteins exhibit homology to the Saccharomyces cerevisiae Mtq2 (also know as PrmC [ ]). Mtq2 methylates eRF1 on 'Gln-182' using S-adenosyl L-methionine as methyl donor. eRF1 needs to be complexed to eRF3 in its GTP-bound form to be efficiently methylated [, , ]. In bacteria, the methylation of RF1/RF2 by PrmC is important for normal growth, to increase the affinity of RF1/RF2 for ribosomes and to enhance translation termination [, ].Human homologue of Mtq2 is called hemK methyltransferase family member 2 (HEMK2, also known as N6AMT1), which is an N6-adenine-specific DNA methyltransferase [ ]. |
Short Name | PrmC-related |