v5.1.0.3
Glycine data from LIS
Type | Family |
Description | This entry represents the eukaryotic Vacuolar protein sorting-associated protein 41 (Vps41), a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex, which is essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport [ , , ]. This protein interacts with Caspase-8, which plays a key role in apoptosis and development []. In humans, Vps41 variants prevent the formation of a functional HOPS complex, causing disorders such as dystonia associated with lysosomal abnormalities and neurodegenerative diseases [ , , ]. |
Short Name | VPS41 |