v5.1.0.3
Glycine data from LIS
Type | Domain |
Description | This entry contains of several mammalian and one bird sequence from Gallus gallus (Chicken) and represents the N-terminal region of repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system, and controls cell motility, adhesion, immune cell regulation and systemic iron metabolism [ , ]. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum []. |
Short Name | RGM_N |