Protein Domain : Mitochondrial carrier protein IPR002067

Type  Family
Description  A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane [ , , , , ]. Such proteins include: ADP/ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Solute carrier family 25 member 16 (also known as Graves disease carrier protein); yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. This family also includes peroxisomal proteins like PMP34 [].Sequence analysis of selected members of the carrier protein family has suggested the presence of six transmembrane (TM) domains, with varying degrees of sequence conservation and hydrophilicity []. The TM regions, and adjacent hydrophilic loops, are more highly conserved than other regions of the proteins []. All members of the family appear to consist of a tripartite structure, each of the repeated segments being about 100 residues in length []. Each repeat contains two TM domains, the first being more hydrophobic, with conserved glycyl and prolyl residues. Five of the six TM domains are followed by the conserved sequence (D/E)-Hy(K/R), where - denotes any residue and Hy is a hydrophobic position [].
Short Name  Mit_carrier

3 Child Features

27 Gene Families

1000 Genes

1 Ontology Annotations

0 Parent Features

14 Publications

USDA
InterMine logo
The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
LegumeMine || ArachisMine | CicerMine | GlycineMine | LensMine | LupinusMine | PhaseolusMine | VignaMine | MedicagoMine
InterMine © 2002 - 2022 Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom