Protein Domain : Phosphoribosyl pyrophosphate synthetase, conserved site IPR000842

Type  Conserved_site
Description  Phosphoribosyl pyrophosphate synthetase ( ) (PRib-PP synthetase) catalyses the formation of PRib-PP from ATP and ribose 5-phosphate. PRib-PP is then used in various biosynthetic pathways, for example in the formation of purines, pyrimidines, histidine and tryptophan. PRib-PP synthetase requires inorganic phosphate and magnesium ions for its stability and activity. In mammals, three isozymes of PRib-PP synthetase are found, while in yeast there are at least four isozymes. A very conserved region containing two conserved aspartic acid residues as well as a histidine has been suggested to be involved in binding divalent cations [ ]. These residues are all potential ligands for a cation such as magnesium.
Short Name  PRib_PP_synth_CS

0 Child Features

0 Gene Families

222 Genes

4 Ontology Annotations

0 Parent Features

13 Publications

USDA
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