Ontology Term : Pfam:PF12460 RNAPII transcription regulator C-terminal EMBL-EBI

Description  MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription [1]. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly [2]. This domain has a HEAT-like repeat structure [3].
Namespace  Repeat

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1 Ontology

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