Ontology Term : Pfam:PF14500 Dos2-interacting transcription regulator of RNA-Pol-II EMBL-EBI
Description  This domain, along with the C-terminal part, Pfam:PF12460 [1], is an essential component of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly [2].
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