LIS - Legume Information System
Information about legume traits for crop improvement
GlycineMine
v5.1.0.3
Glycine data from LIS
v5.1.0.3
Glycine data from LIS
| Type | Family |
| Description | This entry includes membrane insertase YidC from bacteria, ALBINO3-like proteins from plants, and mitochondrial membrane insertase OXA1 and cytochrome c oxidase assembly protein COX18 from eukaryotes. They are a group of evolutionarily conserved proteins that function in membrane protein integration and protein complex stabilization. They share a conserved region composed of five transmembrane regions [ ]. YidC is required for the insertion of integral membrane proteins into the membrane. It may also be involved in protein secretion processes [ ]. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminal and a large periplasmic domain, located between TM1 and TM2, that adopts a β-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase [ , ]. The well-characterised YidC protein from Escherichia coli and its close homologues contain a large N-terminal periplasmic domain (). This protein interacts with SecYEG protein-conducting channel and the accessory proteins SecDF-YajC to form the bacterial holo-translocon (HTL) [ ].COX18 is a mitochondrial membrane insertase required for the translocation of the C-terminal of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. It plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2 [ ].OXA1 is a mitochondrial inner membrane insertase that mediates the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the inner membrane. It links mitoribosomes with the inner membrane [ ].Plant ALBINO3-like proteins are required for the insertion of some light harvesting chlorophyll-binding proteins (LHCP) into the chloroplast thylakoid membrane [ , ]. |
| Short Name | YidC/ALB3/OXA1/COX18 |
