Protein Domain : Aspartic peptidase, DDI1-type IPR019103

Type  Domain
Description  This domain is found in eukaryotic aspartyl protease DDI1 (DNA Damage Inducible protein 1; MEROPS identifier A28.001). The remarkable structural similarity between this central domain of DDI1 and the retroviral proteases suggests that DDI1 functions proteolytically during regulated protein turnover [ , ]. DDI1 has been shown to activate an endoplasmic-reticulum isoform of the transcription factor SKN-1 in Caenorhabditis elegans when the proteasome is dysfunctional []. DDI1 also has an amino-terminal ubiquitin-like domain and/or a UBA (ubiquitin-associated) domain [].
Short Name  Peptidase_aspartic_DDI1-type

1 Child Features

0 Gene Families

198 Genes

2 Ontology Annotations

0 Parent Features

13 Publications

USDA
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