Protein Domain : CXC domain IPR026489

Type  Domain
Description  Polycomb group (Pc-G) proteins ensure the stable inheritance of expression patterns through cell division and regulate the control of cell proliferation.The Enhancer of zeste (E(z))-type of Pc-G proteins includes: Drosophila melanogaster Enhancer of zeste E(z).Mammalian ENX-1 and ENX-2.Arabidopsis thaliana CURLY LEAF (CLF), a transcriptional repressor of floral homeotic gene AGAMOUS.Arabidopsis thaliana CLF-like.Arabidopsis thaliana MEDEA (MEA), a suppressor of endosperm development.Arabidopsis thaliana EZA1.These proteins contain a SET domain at the C terminus.Unique to them is the presence of a CXC domain, an ~65-residue cys-rich region preceding the SET domain. The spacing of 17 cyteines is conserved. The CXCdomain contains three units of C-X(6)-C-X(3)-C-X-C motif, although the most C- terminal unit is reverse-oriented. Because of its evolutionary conservation,the CXC domain is likely to be involved in an important function of E(z)- related proteins [, , ].The CXC domain shows some similarity to the CRC domain found in the tesmin/ TSO1 protein family [].
Short Name  CXC_dom

0 Child Features

2 Gene Families

260 Genes

0 Ontology Annotations

1 Parent Features

14 Publications

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