Ontology Term : Pfam:PF07814 Wings apart-like protein regulation of heterochromatin EMBL-EBI

Description  This family contains sequences expressed in eukaryotic organisms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure [1]. hWAPL (Swiss:Q7Z5K2), the human homologue, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein [2]. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death [2].
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