v5.1.0.3
Glycine data from LIS
Type | Family |
Description | This family includes SWR1-complex protein 5 (Swc5) from fungi, and craniofacial development protein 1 (CFDP1) and 2 (CFDP2) from animals.Swc5 is a component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. It is involved in chromosome stability [ , , ].Gene duplication of the ancestral bnct (bucentaur) gene leads to the h-type bnct (cfdp1) gene and the p97bcnt (cfdp2) gene. Cfdp2 is rumiant-specific, containing a region derived from the endonuclease domain of a retrotransposable element RTE-1 not found in human and mouse [ ]. For this reason bcnt has been used as a model for molecular evolution [, , ]. CFDP1, also known as Cp27, may play a role during embryogenesis []. |
Short Name | Swc5/CFDP1/2 |