Protein Domain : SWR1-complex protein 5/Craniofacial development protein 1/2 IPR027124

Type  Family
Description  This family includes SWR1-complex protein 5 (Swc5) from fungi, and craniofacial development protein 1 (CFDP1) and 2 (CFDP2) from animals.Swc5 is a component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. It is involved in chromosome stability [ , , ].Gene duplication of the ancestral bnct (bucentaur) gene leads to the h-type bnct (cfdp1) gene and the p97bcnt (cfdp2) gene. Cfdp2 is rumiant-specific, containing a region derived from the endonuclease domain of a retrotransposable element RTE-1 not found in human and mouse [ ]. For this reason bcnt has been used as a model for molecular evolution [, , ]. CFDP1, also known as Cp27, may play a role during embryogenesis [].
Short Name  Swc5/CFDP1/2

0 Child Features

2 Gene Families

314 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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