Protein Domain : Dynamin GTPase effector IPR003130

Type  Domain
Description  This entry represents the dynamin GTPase effector domain (GED) found in proteins related to dynamin. Its C-terminal region constitutes one of the helices of the bundle signalling element (BSE) or neck together with the N- and C-terminal regions from the Gtpase domain, being in close proximity and functionally linked to it. The N-terminal region of GED is part of the stalk domain [ ].Dynamin is a GTP-hydrolysing protein that is an essential participant in clathrin-mediated endocytosis by cells. It self-assembles into 'collars' in vivo at the necks of invaginated coated pits; the self-assembly of dynamin being coordinated by the GTPase domain. Mutation studies indicate that dynamin functions as a molecular regulator of receptor-mediated endocytosis [ , ].
Short Name  GED

0 Child Features

0 Gene Families

1000 Genes

2 Ontology Annotations

1 Parent Features

13 Publications

USDA
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