v5.1.0.3
Glycine data from LIS
Type | Family |
Description | Pantothenate kinase (PanK, ) catalyses the conversion of CAATP and pantothenate to ADP and D-4'-phosphopantothenate, the key regulatory step in the biosynthesis of coenzyme A (CoA) [ ]. Members in this entry represents a two-domain form with an additional C-terminal domain of unknown function. This type of pantothenate kinase is typical for eukaryotes. It is not related by sequence to bacterial PanK () and differs in a number of biochemical properties (such as inhibition by acetyl-CoA) [ , ]. However, this group also includes proteins from several Gram-positive bacteria () that are suggested to have originated from the eukaryotic form by lateral transfer [ ].Hallervorden-Spatz syndrome is caused by a defect in a pantothenate kinase gene [ ].For additional information please see [ ]. |
Short Name | PanK_long |