v5.1.0.3
Glycine data from LIS
Type | Family |
Description | Bicarbonate (HCO 3-) transport mechanisms are the principal regulators of pH in animal cells. Such transport also plays a vital role in acid-base movements in the stomach, pancreas, intestine, kidney, reproductive organs and the central nervous system. Functional studies have suggested four different HCO 3-transport modes. Anion exchanger proteins exchange HCO 3-for Cl -in a reversible, electroneutral manner [ ]. Na+/HCO 3-co-transport proteins mediate the coupled movement of Na +and HCO 3-across plasma membranes, often in an electrogenic manner [ ]. Na+driven Cl -/HCO 3-exchange and K +/HCO 3-exchange activities have also been detected in certain cell types, although the molecular identities of the proteins responsible remain to be determined. Sequence analysis of the two families of HCO 3-transporters that have been cloned to date (the anion exchangers and Na +/HCO 3-co-transporters) reveals that they are homologous. This is not entirely unexpected, given that they both transport HCO 3-and are inhibited by a class of pharmacological agents called disulphonic stilbenes [ ]. They share around ~25-30% sequence identity, which is distributed along their entire sequence length, and have similar predicted membrane topologies, suggesting they have ~10 transmembrane (TM) domains. |
Short Name | HCO3_transpt_euk |