v5.1.0.3
Glycine data from LIS
Type | Family |
Description | Members of the 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthetase family ( ) catalyse the first step in aromatic amino acid biosynthesis from chorismate. Class I (see ) includes bacterial and yeast enzymes; class II includes higher plants and various microorganisms [ ]. They have minimal sequence identity and different regulatory and oligomeric properties, however, they have structural similarities that indicate a common ancestry for the class I and class II DAHPSs [].The first step in the common pathway leading to the biosynthesis of aromatic compounds is the stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) [ ]. This reaction is catalyzed by DAHP synthase, a metal-activated enzyme, which in microorganisms is the target for negative-feedback regulation by pathway intermediates or by end products. |
Short Name | DAHP_synth_2 |