Protein Domain : Mon2/Sec7/BIG1-like, HDS IPR015403

Type  Domain
Description  This entry represents a HDS (homology downstream of Sec7) domain found towards the C-terminal of guanine nucleotide exchange factors involved Golgi transport, such as budding yeast protein Sec7, protein Mon2 and BIG1-like proteins [ , ]. Sec7 is involved in the secretory pathway as a protein binding scaffold for the COPII-COPI protein switch for maturation of the VTC intermediate compartments for Golgi compartment biogenesis []. Sec7 has four conserved HDS1-4 domains which act to integrate the signals from several small GTPases, including Arf1 itself, to switch Sec7 from a strongly autoinhibited to a strongly auto activated form [].
Short Name  Mon2/Sec7/BIG1-like_HDS

0 Child Features

0 Gene Families

452 Genes

0 Ontology Annotations

0 Parent Features

13 Publications

USDA
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