Protein Domain : Invasin/intimin cell-adhesion fragments IPR008964

Type  Homologous_superfamily
Description  Two types of pathogenic Escherichia coli, enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC), cause diarrhoeal disease by disrupting the intestinal environment through the intimate attachment of the bacteria to the intestinal epithelium. This process is mediated by intimin, an outer membrane protein that is homologous to the invasins of pathogenic Yersinia. EPEC and EHEC form characteristic lesions on infected mammalian cells called actin pedestals. Each of these two pathogens injects its own translocated intimin receptor (Tir) molecule into the plasma membranes of host cells. Interaction of translocated Tir with the bacterial outer membrane protein intimin is required to trigger the assembly of actin into focused pedestals beneath bound bacteria [ ].
Short Name  Invasin/intimin_cell_adhesion

0 Child Features

1 Gene Families

57 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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