GO Term : GO:0070578 RISC-loading complex Gene Ontology

Description  A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
Namespace  cellular_component
Obsolete  false

1 Data Sets

Trail: GOTerm

1 Ontology

Trail: GOTerm

1 Ontology Annotations

Trail: GOTerm

7 Parents

Trail: GOTerm

7 Relations

Trail: GOTerm

3 Synonyms

Trail: GOTerm
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