Protein Domain : Ribosomal protein S5 domain 2-type fold IPR020568

Type	Homologous_superfamily
Description	Domain 2 of the ribosomal protein S5 has a left-handed, 2-layer α/β fold with a core structure consisting of β(3)-α-β-α. Domains with this fold are found in numerous RNA/DNA-binding proteins, as well as in kinases from the GHMP kinase family. Proteins containing this α/β fold domain include: Translational machinery components (ribosomal proteins S5 and S9, and domain IV of elongation factors EF-G and eEF-2) [ ].Ribonuclease P protein (RNase P) [ ].Ribonuclease PH (domain 1) [ ], as well as various exosome complex exonucleases (RRP41, RRP42, RRP43, RRP45, RRP46, MTR3, ECX1, ECX2) [].DNA modification proteins (DNA mismatch repair proteins MutL and PMS2, DNA gyrase B, DNA topoisomerase II, IV-B and VI-B) [ ]. GHMP kinases that transfer a phosphoryl group from ATP to an acceptor (galactokinase ( ), homoserine kinase ( ), and mevalonate kinase ( )) [ , ].Caenorhabditis elegans early switch protein Xol-1 (a divergent member of the GHMP kinase family that has lost the ATP-binding site) [ ].Hsp90 chaperone (middle domain), which is related to the DNA gyrase/MutL family [ ]; this domain contains an extra C-terminal α/β subdomain.Imidazole glycerol phosphate dehydratase, which contains a duplication consisting of two structural repeats of this fold [ ].The catalytic domain of ATP-dependent protease Lon (La), which contains an extra C-terminal α/β subdomain [ ].Formaldehyde-activating enzyme FAE, which contains a modification of this fold consisting of an extra α/β unit after strand 2 [ ].
Short Name	Ribosomal_S5_D2-typ_fold