v5.1.0.3
Glycine data from LIS
Type | Homologous_superfamily |
Description | Isopenicillin N synthase (IPNS) catalyses conversion of the linear tripeptide delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV) to isopenicillin N (IPN), the central step in biosynthesis of the beta-lactam antibiotics [ ]. IPNS is a nonhaem-Fe2+-dependent enzyme. It belongs to a class of nonhaem Fe2+-containing enzymes which includes 2-oxoglutarate-dependent dioxygenases, 2-oxoglutarate-dependent hydroxy- lases, and enzymes involved in ethylene formation and anthocyaninidin biosynthesis.The IPNS structure shows that the active site is buried within the hydrophobic pocket of an eight-stranded jelly roll barrel [ , ]. |
Short Name | IPNS-like_sf |