Protein Domain : Mu homology domain IPR028565

Type	Domain
Description	The mu homology domain (MHD) is an ~280 residue protein-protein interaction module, which is found in endocytotic proteins involved in clathrin-mediatedendocytosis [ , , , ]:Mu subunits of adaptor protein (AP) complexes, AP-1, AP-2, AP-3, and AP-4.Proteins of the stonin family.Proteins of the muniscin family: Syp1, FCHO1/2 and SGIP1.The MHD domain has an elongated, banana-shaped, all β-sheet structure. It can be considered as two β-sandwich subdomains (A and B), with subdomain B inserted between strands 6 and 15 of subdomain A, and joined edge to edge such that the convex surface is a continuous nine-stranded mixed β-sheet that runs the whole length of the molecule. The tyrosine based signal binds to a site on the surface of two parallel β-sheet strands (beta1 and beta16) in subdomain A [, ].
Short Name	MHD