Protein Domain : Clathrin adaptor, mu subunit, conserved site IPR018240

Type	Conserved_site
Description	This entry represents the mu subunit of various clathrin adaptors (AP1, AP2 and AP3) [ ]. The mu subunit regulates the coupling of clathrin lattices with particular membrane proteins by self-phosphorylation via a mechanism that is still unclear []. The mu subunit possesses a highly conserved N-terminal domain of around 230 amino acids, which may be the region of interaction with other AP proteins; a linker region of between 10 and 42 amino acids; and a less well-conserved C-terminal domain of around 190 amino acids, which may be the site of specific interaction with the protein being transported in the vesicle [].
Short Name	Clathrin_mu_CS