Protein Domain : Transcription elongation factor Spt6 IPR017072

Type	Family
Description	Spt6 is an essential histone chaperone that mediates nucleosome reassembly during gene transcription. The N-terminal ~300 residues are highly acidic, predicted to be disordered, and are necessary for binding both nucleosomes and the transcription factor Spn1/IWS1 [ ]. Spt6 associates with RNAPII via a tandem Src2 homology domain [, ]. Spt6-RNAPII association is required for efficient recruitment of the Ccr4-Not de-adenylation complex to transcribed genes for mRNA turnover [ ]. Spt6 has a key function in transcription elongation. In yeast, Spt6's interaction with phosphorylated tyrosine 1 at the C-terminal domain of RNAPII prevents pre-mature recruitment of termination factors to genes [].
Short Name	TF_Spt6