Protein Domain : Protein Networked (NET), actin-binding (NAB) domain IPR011684

Type	Domain
Description	This entry represents the NAB domain found in the Networked proteins.The Networked (NET) proteins are a superfamily of plant-specific actin-binding proteins which localize simultaneously to the actin cytoskeleton and specificmembrane compartments and are suggested to couple these membranes to the actin cytoskeleton in plant cells. The minimal actin binding region, referred to asthe NET actin-binding (NAB) domain, represents a new actin binding motif unique to plants with no apparent primary sequence homolgy to previouslyidentified actin binding domains. In Arabidopsis, the NAB domain always starts with three conserved tryptophan residues, WWW, a motif whose worldwide webconnection gives added significance to the NET family name. The C-terminal half of the domain is very highly conserved, more so than the N-terminal[ , ].The predicted secondary structure of the domain includes three major alpha helices connected by a beta turns with the WWW motif predicted to form a betasheet [ , ].
Short Name	NAB