Protein Domain : DNA-directed RNA polymerase subunit RPABC5/Rpb10 IPR000268

Type	Family
Description	In eukaryotes, there are three different forms of DNA-dependent RNA polymerases ( ) transcribing different sets of genes. Each class of RNA polymerase is an assemblage of ten to twelve different polypeptides. In archaebacteria, there is generally a single form of RNA polymerase which also consists of an oligomeric assemblage of 10 to 13 polypeptides. Archaebacterial subunit Rpo10 (gene rpoN) [] is a small protein of about 8kDa, it is evolutionary related [] to a 8.3kDa component shared by all three forms of eukaryotic RNA polymerases (RPABC5, gene Rpb10 in yeast and POLR2J in mammals) as well as to African swine fever virus (ASFV) protein CP80R [].This family includes both archaeal subunit N, also known as Rpo10 following the eukaryotic nomenclature [ ], and eukaryotic Rpb10. There is a conserved region which is located at the N-terminal extremity of these polymerase subunits; this region contains two cysteines that bind a zinc ion [].
Short Name	RPABC5/Rpb10