Protein Domain : HAUS augmin-like complex subunit 2 IPR028346

Type	Family
Description	This entry represents HAUS augmin-like complex subunit 2 from animals (HAUS2) and plants (AUG2) [ , ]. The HAUS (Homologous to AUgmin Subunits) individual subunits have been designated HAUS1 to HAUS8 [ ]. In animals, HAUS augmin-like complex subunit 2 is a component of the HAUS augmin-like complex, which localises to the centrosomes and interacts with the gamma-tubulin ring complex (gamma-TuRC) []. The interaction between augmin and gamm-TuRC is important for spindle microtubule generation and affects the mitotic progression and cytokinesis []. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis []. The HAUS augmin-like complex subunit 2 was previously known as centrosomal protein of 27kDa (Cep27).In plants, the augmin complex contains 8 subunits, including two plant-specific subunits [ ]. Despite lacking cetrosomes, the augmin complex in plants plays an important part in gamma-tubulin-dependent MT nucleation and the assembly of microtubule arrays during mitosis [].
Short Name	HAUS2