v5.1.0.3
Glycine data from LIS
Type | Repeat |
Description | These repeats were first identified in many cyanobacterial proteins but they are also found in bacterial as well as in plant proteins [ ]. The repeats were first identified in hglK [ ]. Pentapeptide repeat proteins (PRPs) are characterised by the repetition of the pentapeptide repeat motif [S,T,A,V][D,N][L,F][S,T,R][G], which allows it to adopt a right-handed β-helical structure conformation [ ]. The functions of these repeats is unknown but it has been shown that members of this family share the ability to interact with DNA-binding proteins, such as DNA gyrase. For example, McbG (from Escherichia coli) protects the DNA gyrase from microcin B17 toxicity, MfpAMt (from Mycobacterium tuberculosis) and Qnr (from Klebsiella pneumoniae and other enterobacteria) are involved in resistance to fluoroquinolones []. |
Short Name | 5peptide_repeat |