Protein Domain : THO complex subunit 7/Mft1 IPR008501

Type	Family
Description	The THO complex (THOC) is involved in transcription elongation and mRNA export from the nucleus [ ]. This entry represents the subunit THOC7, which is found in higher eukaryotes, and the non-homologous subunit Mft1 found in yeast. Mft1 is a component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export [ ]. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription []. THO is important for stabilising nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase []. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase Sub2 and the mRNA export factor Yra1 along the nascent mRNA []. In mammals, the THO complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. It binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export [ , ].
Short Name	THOC7/Mft1