Protein Domain : Association with the SNF1 complex (ASC) domain IPR006828

Type	Domain
Description	Association with the SNF1 complex (ASC) domain is found in the Sip1/Sip2/Gal83/AMPKbeta subunits of the SNF1/AMP-activated protein kinase (AMPK) complex [ ]. SNF1/AMPK are heterotrimeric enzymes composed of a catalytic alpha-subunit, a regulatory gamma-subunit and a regulatory/targeting beta-subunit []. Saccharomyces cerevisiae encodes three beta-subunit genes, Sip1, Sip2 and Gal83 [, ]. The beta-subunits function as target selective adaptors that recruit the catalytic kinase and regulator Snf4/gamma-subunits. The ASC domain is required for interaction with Snf4 [, ].The SNF1 kinase complex is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation [ , ]. As glucose levels decrease, Snf1 is activated and promotes the use of alternative carbon sources.
Short Name	ASC_dom