Protein Domain : Acetolactate synthase, large subunit, biosynthetic IPR012846

Type	Family
Description	Two groups of proteins form acetolactate from two molecules of pyruvate. The type of acetolactate synthase described in this entry also catalyzes the formation of acetohydroxybutyrate from pyruvate and 2-oxobutyrate, an early step in the branched chain amino acid biosynthesis; it is therefore also termed acetohydroxyacid synthase. In bacteria, this catalytic chain is associated with a smaller regulatory chain in an alpha2/beta2 heterotetramer. Acetolactate synthase is a thiamine pyrophosphate enzyme. In this type, FAD and Mg++ are also found. Several isozymes of this enzyme are found in Escherichia coli (strain K12), one of which contains a frameshift in the large subunit gene and is not expressed.
Short Name	Acetolactate_synth_lsu