Protein Domain : TPP-binding enzyme, conserved site IPR000399

Type	Conserved_site
Description	A number of enzymes require thiamine pyrophosphate (TPP) (vitamin B1) as a cofactor. It has been shown [ ] that some of these enzymes are structurally related.Enzymes with a TPP-binding domain include: Pyruvate oxidase (POX) ( ). Reaction catalysed: pyruvate + orthophosphate + O(2) + H(2)O = acetyl phosphate + CO(2) + H(2)O(2). Pyruvate decarboxylase (PDC) ( ) [ ].Reaction catalysed: pyruvate = acetaldehyde + CO(2). Indolepyruvate decarboxylase ( ) [ ]. Reaction catalysed: indole-3-pyruvate = indole-3-acetaldehyde + CO(2).Acetolactate synthase (ALS) ( ). Reaction catalysed: 2x pyruvate = acetolactate + CO(2).Benzoylformate decarboxylase (BFD) ( ) [ ]. Reaction catalysed: benzoylformate = benzaldehyde + CO(2).
Short Name	TPP-bd_CS