Protein Domain : Protein LIN-9/Protein ALWAYS EARLY IPR010561

Type	Family
Description	This entry represents protein LIN-9/ALWAYS EARLY (LIN-9/ALY). LIN-9 from Caenorhabditis elegans is a homologue of the Drosophila always early (ALY) protein, which functions as a repressor of cell cycle regulated genes [ , ].LIN-9 is a component of the evolutionary conserved DREAM (MuvB/DRM) complex, which represses transcription [ ]. DREAM complex undergoes a cell cycle dependent switch of subunits. DREAM core binds to the E2F4 transcription factor and to the RBL2 (p130) in quiescent cells, while associates with the transcription factor B-MYB in the S-phase []. In humans, LIN-9 acts as a tumor suppressor and plays a role in the expression of genes required for the G1/S transition [, ]. In pluripotent embryonic stem cells (ESC), LIN-9 plays an important role for proliferation and genome stability by activating genes with important functions in mitosis and cytokinesis [].In Arabidopsis thaliana, ALY is expressed ubiquitously in vegetative and reproductive tissues [ ].
Short Name	LIN-9/ALY1