Protein Domain : Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2 IPR019453

Type  Domain
Description  This entry represents a domain found in the vacuolar sorting protein Vps39 and transforming growth factor beta receptor-associated protein Trap1. Vps39, a component of the C-Vps complex, is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole [ , ]. In Saccharomyces cerevisiae (Baker's yeast), Vps39 has been shown to stimulate nucleotide exchange []. Trap1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling [, ]. The precise function of this domain has not been characterised In Vps39 this domain is involved in localisation and in mediating the interactions with Vps11 [].
Short Name  VPS39/TGF_beta_rcpt-assoc_2

0 Child Features

3 Gene Families

244 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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