Protein Domain : Ribosomal RNA methyltransferase, SPB1-like, C-terminal IPR012920

Type  Domain
Description  This domain is found at the C terminus SPB1-like proteins. This domain interacts with the meandering tail of Erb1 and its removal is required to form the pre-mature inter-subunit surface of the Arx1/Nog2 particle [ , ].SPB1 is an adoMet-dependent rRNA methyltransferase required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit [ ]. In Saccharomyces cerevisiae, it specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation []. It interacts with the snoRNA-associated proteins Nop1 and Nop58 []. FTSJ3, SPB1 homologue in humans, is associated with NIP7 (involved in the biogenesis of 40S subunit) and functions in pre-rRNA processing [ ].
Short Name  rRNA_MeTfrase_SPB1-like_C
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0 Child Features

0 Gene Families

116 Genes

Trail: ProteinDomain

3 Ontology Annotations

Trail: ProteinDomain

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13 Publications

Trail: ProteinDomain
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