Protein Domain : Galactokinase/homoserine kinase IPR001174

Type	Family
Description	The lincomycin (LM)-production gene cluster of an over-producing strain of Streptomyces lincolnensis has been analysed []. The lmb/lmr gene cluster contains 27 open reading frames with putative biosynthetic or regulatory functions (lmb genes) and three resistance (lmr) genes []. Only a minority of the putative Lmb proteins belong to known proteinfamilies: these include members of the gamma-glutamyl transferases (LmbA); amino acid acylases (LmbC); aromatic amino acid aminotransferases (LmbF);imidazoleglycerolphosphate dehydratases (LmbK); dTDP-glucose synthases (LmbO); dTDP-glucose 4,6-dehydratases (LmbM); and (NDP-) ketohexose (or ketocyclitol) aminotransferases (LmbS) [ ]. LmbP seems to show some similarity to a family of enzymes that share anN-terminal Gly/Ser-rich putative ATP-binding region: these include galacto- kinase (), homoserine kinase ( ), mevalonate kinase ( ) and phosphomevalonate kinase []. Sequence v031 from Mycobacterium tuberculosis [] is also a homologue.
Short Name	Galkinase