Protein Domain : Hydroxyethylthiazole kinase IPR000417

Type	Family
Description	Most microorganisms and plants can synthesise thiamin de novo [ ]. In this de novo pathway, the thiazole and pyrimidine moieties of thiamin are made separately and coupled together to form thiamin phosphate. For the thiazole moiety, 4-methyl-5-(2-hydroxyethyl)thiazole (THZ), the key salvage step is phosphorylation to give 4-methyl-5-(2-phosphonooxyethyl)thiazole (THZ-P). The enzyme hydoxyethylthiazole kinase () is responsible for this step. Hydoxyethylthiazole kinase is encoded by thiM in Escherichia coli [ ] and other bacteria [, ], and by the C-terminal region of bifunctional proteins in some cases, such as Saccharomyces cerevisiae, in which the N-terminal domain corresponds to the bacterial thiamine-phosphate pyrophosphorylase (), ThiE [ , ]. ThiM constitutes a potential target for pro-drug compounds for antibacterial drug development.The Arabidopsis and maize genomes encode homologues of ThiM [ ].
Short Name	Hyethyz_kinase