Protein Domain : Mitochondrial carrier UCP-like IPR002030

Type	Family
Description	This protein family includes a variety of substrate carrier proteins that are involved in energy transfer and are found in the inner mitochondrial membrane [ , , , , ]. UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat.Mitochondrial brown fat uncoupling protein 1 from chordates (UCP1) from chordates is responsible for thermogenic respiration, a specialised capacity of brown adipose tissue to the regulation of energy balance. It regulates the production of reactive oxygen species/ROS by mitochondria [ , ].The protein has a tripartite structure, with each of the 3 similar domains displaying a transmembrane helix, a loop, an amphipathic helix and another transmembrane helix. Overall, it shows a channel-like structure [ ].The domains exhibit striking conservation of several residues, especially of glycine and proline, which may constitute structurally strategicpositions [ ].
Short Name	Mit_uncoupling_UCP-like