v5.1.0.3
Glycine data from LIS
Type | Domain |
Description | Initiation factor 2 (IF-2) is one of the three factors required for the initiation of protein biosynthesis in bacteria [ ]. IF-2 promotes the GTP-dependent binding of the initiator tRNA to the small subunit of the ribosome. IF-2 is a protein of about 70 to 95kDa that contains a central GTP-binding domain flanked by a highly variable N-terminal domain and a more conserved C-terminal domain. Some members of this group undergo protein self splicing that involves a post-translational excision of the intein followed by peptide ligation.The function of IF-2 in facilitating the proper binding of initiator methionyl-tRNA to the ribosomal P site appears to be universally conserved [ ].This entry represents the domain 3 of IF-2. It consists of a α/β/α structure with a core formed by a parallel β-sheet of 4 strands [ ]. |
Short Name | TIF_IF2_dom3 |