Protein Domain : mRNA decay factor PAT1 domain IPR019167

Type	Domain
Description	This entry represents a domain found in Pat1 and its homologues. Pat1 is involved in translational repression and enhanced mRNA decay. It is part of the Lsm1-7-Pat1 complex that plays a role in activation of deadenylation-dependent decapping in the 5' to 3' pathway and in the protection of mRNA 3' ends [ ].There are two Pat1 homologues in vertebrates, Pat1a and Pat1b, in contrast to the single protein in yeast and invertebrates. The maternally expressed Pat1a protein acts as a translational repressor, while Pat1b functions in mRNA decay in somatic cells. Pat1b is localised to P-body and is a nucleocytoplasmic shuttling protein that may perform various nuclear functions upstream of their multiple posttranscriptional regulatory roles in the cytoplasm [ ].
Short Name	PAT1_dom