Protein Domain : CGI121/TPRKB IPR013926

Type	Family
Description	This entry represents the EKC/KEOPS complex subunit Cgi121 from fungi and its homologue, TPRKB from mammals. This entry also includes archaeal homologues [ ]. CGI121 is part of the KEOPS complex, which is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine [ ]. The KEOPS complex also plays an important part in telomere uncapping and telomere elongation and is required for efficient recruitment of transcriptional coactivators []. TPRKB has been shown to bind to the p53-related protein kinase (PRPK) [ ]. PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53.
Short Name	CGI121/TPRKB