Protein Domain : E3 SUMO-protein ligase Nse2 (Mms21) IPR026846

Type  Family
Description  This entry consists of the E3 SUMO-protein ligase Nse2 (also known as Mms21). Nse2 is an E3 SUMO-protein ligase component of the SMC5-SMC6 complex [ , ]. Nse2 acts as an E3 ligase targeting several proteins for sumoylation and is required for efficient DNA repair and maintenance of genome stability [, , , ]. Nse2 and SMC5 may also be required for sister chromatid cohesion during prometaphase and mitotic progression; this role is apparently independent of SMC6 []. Nse2 is necessary for normal cell cycle progression in Arabidopsis, where Nse2 mutation results in abnormal root development [].
Short Name  Nse2(Mms21)

0 Child Features

1 Gene Families

59 Genes

3 Ontology Annotations

0 Parent Features

13 Publications

USDA
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