Protein Domain : FeS cluster insertion protein IPR016092

Type	Family
Description	Proteins in this entry include HesB, IscA, SufA and ErpA, and appear to be scaffold proteins upon which 2Fe-2S clusters are assembled and subsequently transferred to acceptor proteins. Several multiprotein complexes, referred to as ISC, SUF, and NIF, are known to be necessary for building and inserting Fe-S clusters into cellular targets [ ]. The HesB proteins are associated with the nif gene cluster. The Escherichia coli SufA protein is associated with SufS, a NifS homologue, and SufD which are involved in the FeS cluster assembly of the FhnF protein []. The Azotobacter protein IscA (homologues of which are also found in E. coli) is associated which IscS, another NifS homologue, and IscU, a NifU homologue, as well as other factors consistent with a role in FeS cluster chemistry []. ErpA is required, together with IscA, for the delivery of iron-sulphur clusters to the hydrogen-oxidizing [NiFe]-hydrogenases in Escherichia coli [ , ].
Short Name	FeS_cluster_insertion