Ontology Term : Pfam:PF13919 Asx homology domain EMBL-EBI

Description  A conserved alpha helical domain with a characteristic LXXLL motif [1] [2]. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them [3]. The ASXH domain is found in animals, fungi and plants [4] and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs [4].
Namespace  Domain

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