Ontology Term : Pfam:PF12214 Cell cycle regulated microtubule associated protein EMBL-EBI

Description  This domain is found in eukaryotes. This domain is typically between 127 to 182 amino acids in length. This domain is found associated with Pfam:PF06886. This domain is found in the protein TPX2 (a.k.a p100) which is involved in cell cycling. It is only expressed between the start of the S phase and completion of cytokinesis. The microtubule-associated protein TPX2 has been reported to be crucial for mitotic spindle formation. This domain is close to the C terminal of TPX2. The protein importin alpha regulates the activity of TPX2 by binding to the nuclear localisation signal in this domain.
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