Ontology Term : Pfam:PF10358 N-terminal C2 in EEIG1 and EHBP1 proteins EMBL-EBI

Description  This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1) [1], and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing [2]. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light [2].
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