Ontology Term : Pfam:PF11566 PI31 proteasome regulator N-terminal EMBL-EBI

Description  PI31 is a regulatory subunit of the immuno-proteasome which is an inhibitor of the 20 S proteasome in vitro.PI31 is also an F-box protein Fbxo7.Skp1 binding partner which requires an N terminal FP domain in both proteins for the interaction to occur via the FP beta sheets. The structure of PI31 FP domain contains a novel alpha/beta-fold and two intermolecular contact surfaces [1]. This is the N-terminal domain of the members.
Namespace  Family

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55 Data Sets

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