Ontology Term : Pfam:PF04179 Rit1 DUSP-like domain EMBL-EBI

Description  This enzyme (EC:2.4.2.-) modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the modification donor. As the initiator tRNA participates both in the initiation and elongation of translation, the 2'-O-ribosyl phosphate modification discriminates the initiator tRNAs from the elongator tRNAs [1]. This C-terminal domain shows similarity to dual specificity phosphatases [2].
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1 Ontology

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123 Ontology Annotations

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