Protein Domain : Axin interactor, dorsalization-associated protein, N-terminal domain superfamily IPR036818

Type  Homologous_superfamily
Description  This entry represents the N-terminal domain of the axin interactor, dorsalization-associated protein (AIDA) superfamily [ ]. AIDA acts as a ventralizing factor during embryogenesis. It inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by axin/JNK-signaling []. The core structure of the AIDA N-terminal domain consists of four helices arranged in a close or partly open bundle fold with left-handed twist going up-and-down.
Short Name  AIDA_N_sf

0 Child Features

0 Gene Families

0 Genes

0 Ontology Annotations

0 Parent Features

0 Publications

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