Protein Domain : Janus kinase and microtubule-interacting protein IPR024836

Type	Family
Description	Janus kinase and microtubule interacting proteins (JAKMIPs) are predominantly expressed in neural tissues and lymphoid organs. Three family members have been identified, termed JAKMIP1-3. They contain an N-terminal region that targets the protein to microtubule polymers and a C-terminal region that is able to associate with Janus kinase (Jak) family members, such as Tyk2 or Jak1 [ ]. The proteins may have a role in Jak signalling and regulation of microtubule cytoskeleton rearrangements.JAKMIP1 has also been shown to interact with GABA(B) receptor R1 subunits [ ], and may be involved in microtubule-dependent transport of the GABA-B receptor [].
Short Name	JAKMIP